Инкю Кси
Департамент
Школа естественных, социальных и гуманитарных наук, Биология, National Laboratory Astana, Laboratory of Biophotonics and imaging, Immunobiology Laboratory Позиция
Ассистент профессор Офис
7114 Электр. почта
yingqiu.xie@old.nu.edu.kz Therapeutic potential of a scorpion venom-derived antimicrobial peptide and its homologs against antibiotic-resistant Gram-positive bacteria
Liu, G., Yang, F., Li, F., Li, Z., Lang, Y., Shen, B., Wu, Y., Li, W., Harrison, P., Strong, P., Xie, Y., Miller, K., Cao, Z., 2018 In : Frontiers in Microbiology. 9, MAY,
Re: Long-term Psychological and Quality-of-life Effects of Active Surveillance and Watchful Waiting After Diagnosis of Low-risk Localised Prostate Cancer
Ibragimova, N., Zhanzak, Z., Meyerbekova, A., Xie, Y., 2018 In : European Urology. 73, 1, p. 143-144
Dysregulation of YAP by ARF Stimulated with Tea-derived Carbon Nanodots
Xie, Y., Sun, Q., Nurkesh, A., Lu, J., Kauanova, S., Feng, J., Tursynkhan, D., Yang, Q., Kassymbek, A., Karibayev, M., Duisenova, K., Fan, H., Wang, X., Manarbek, L., Maipas, A., Chen, Z., Balanay, M., 2017 In : Scientific Reports. 7, 1,
PSA and Prostate Health Index based prostate cancer screening in a hereditary migration complicated population: Implications in precision diagnosis
Akizhanova, M., Iskakova, E., Kim, V., Wang, X., Kogay, R., Turebayeva, A., Sun, Q., Zheng, T., Wu, S., Miao, L., Xie, Y., 2017 In : Journal of Cancer. 8, 7, p. 1223-1228
SKP2 loss destabilizes EZH2 by promoting TRAF6-mediated ubiquitination to suppress prostate cancer
Lu, W., Liu, S., Li, B., Xie, Y., Izban, M., Ballard, B., Sathyanarayana, S., Adunyah, S., Matusik, R., Chen, Z., 2017 In : Oncogene. 36, 10, p. 1364-1373
Inhibition of Cancer Cell Proliferation by Carbon Dots Derived from Date Pits at Low-Dose
Xie, Y., Filchakova, O., Yang, Q., Yesbolatov, Y., Tursynkhan, D., Kassymbek, A., Bouhrara, M., Wang, K., Balanay, M., Fan, H., 2017 In : ChemistrySelect. 2, 14, p. 4079-4083
Analysis of origin and protein-protein interaction maps suggests a distinct oncogenic role of nuclear EGFR during cancer evolution
Sharip, A., Abdukhakimova, D., Wang, X., Kim, A., Kim, Y., Sharip, A., Orakov, A., Miao, L., Sun, Q., Chen, Y., Chen, Z., Xie, Y., 2017 In : Journal of Cancer. 8, 5, p. 903-912
Reverse the resistance to PARP inhibitors
Kim, Y., Kim, A., Sharip, A., Sharip, A., Jiang, J., Yang, Q., Xie, Y., 2017 In : International Journal of Biological Sciences. 13, 2, p. 198-208
Tumor Promoting Aspects of Senescence in Cancer Progression
Yang, Q., Xie, Y., Miao, L., 2016 In : Cancer Investigation. 34, 9, p. 452-458
Role of yes-associated protein in cancer: An update (Review)
Abylkassov, R., Xie, Y., 2016 In : Oncology Letters. 12, 4, p. 2277-2282
A scorpion defensin BmKDfsin4 inhibits hepatitis B virus replication in vitro
Zeng, Z., Zhang, Q., Hong, W., Xie, Y., Liu, Y., Li, W., Wu, Y., Cao, Z., 2016 In : Toxins. 8, 5,
Pim-1 kinase as cancer drug target: An update (Review)
Tursynbay, Y., Zhang, J., Li, Z., Tokay, T., Zhumadilov, Z., Wu, D., Xie, Y., 2016 In : Biomedical Reports. 4, 2, p. 140-146
MMP7 interacts with ARF in nucleus to potentiate tumor microenvironments for prostate cancer progression in vivo
Xie, Y., Lu, W., Liu, S., Yang, Q., Shawn Goodwin, J., Sathyanarayana, S., Pratap, S., Chen, Z., 2016 In : Oncotarget. 7, 30, p. 47609-47619
Identifying actionable targets through integrative analyses of GEM model and human prostate cancer genomic profiling
Wanjala, J., Taylor, B., Chapinski, C., Hieronymus, H., Wongvipat, J., Chen, Y., Nanjangud, G., Schultz, N., Xie, Y., Liu, S., Lu, W., Yang, Q., Sander, C., Chen, Z., Sawyers, C., Carver, B., 2015 In : Molecular Cancer Therapeutics. 14, 1, p. 278-288
SKP2 inactivation suppresses prostate tumorigenesis by mediating JARID1B ubiquitination
Lu, W., Liu, S., Li, B., Xie, Y., Adhiambo, C., Yang, Q., Ballard, B., Nakayama, K., Matusik, R., Chen, Z., 2015 In : Oncotarget. 6, 2, p. 771-788
Slug regulates E-cadherin repression via p19Arf in prostate tumorigenesis
Xie, Y., Liu, S., Lu, W., Yang, Q., Williams, K., Binhazim, A., Carver, B., Matusik, R., Chen, Z., 2014 In : Molecular Oncology. 8, 7, p. 1355-1364
Crosstalk between nuclear MET and SOX9/β-catenin correlates with castration-resistant prostate cancer
Xie, Y., Lu, W., Liu, S., Yang, Q., Carver, B., Li, E., Wang, Y., Fazli, L., Gleave, M., Chen, Z., 2014 In : Molecular Endocrinology. 28, 10, p. 1629-1639
Pim-1 Kinase Phosphorylates and Stabilizes 130 kDa FLT3 and Promotes Aberrant STAT5 Signaling in Acute Myeloid Leukemia with FLT3 Internal Tandem Duplication
Natarajan, K., Xie, Y., Burcu, M., Linn, D., Qiu, Y., Baer, M., 2013 In : PLoS One. 8, 9,
ARF represses androgen receptor transactivation in prostate cancer
Lu, W., Xie, Y., Ma, Y., Matusik, R., Chen, Z., 2013 In : Molecular Endocrinology. 27, 4, p. 635-648
Curcumin suppresses the growth and metastasis of prostate cancer cells by downregulation of Skp2
Gong, Y., Lu, W., Xie, Y., Yang, Q., Matusik, R., Chen, Z., 2012 Prostate Cancer Cells: Detection, Growth and Treatment. Nova Science Publishers, Inc., p. 87-102
Differential regulation of androgen receptor by P1M-1 kinases via phosphorylation-dependent recruitment of distinct ubiquitin E3 ligases
Linn, D., Yang, X., Xie, Y., Alfano, A., Deshmukh, D., Wang, X., Shimelis, H., Chen, H., Li, W., Xu, K., Chen, M., Qiu, Y., 2012 In : Journal of Biological Chemistry. 287, 27, p. 22959-22968
Inhibition of the Rho GTPase, Rac1, decreases estrogen receptor levels and is a novel therapeutic strategy in breast cancer
Rosenblatt, A., Garcia, M., Lyons, L., Xie, Y., Maiorino, C., Désiré, L., Slingerland, J., Burnstein, K., 2011 In : Endocrine-Related Cancer. 18, 2, p. 207-219
Pim-1 kinase protects P-glycoprotein from degradation and enables its glycosylation and cell surface expression
Xie, Y., Burcu, M., Linn, D., Qiu, Y., Baer, M., 2010 In : Molecular Pharmacology. 78, 2, p. 310-318
A role for OCT4 in tumor initiation of drug-resistant prostate cancer cells
Linn, D., Yang, X., Sun, F., Xie, Y., Chen, H., Jiang, R., Chen, H., Chumsri, S., Burger, A., Qiu, Y., 2010 In : Genes and Cancer. 1, 9, p. 908-916
The 44-kDa Pim-1 kinase phosphorylates BCRP/ABCG2 and thereby promotes its multimerization and drug-resistant activity in human prostate cancer cells
Xie, Y., Xu, K., Linn, D., Yang, X., Guo, Z., Shimelis, H., Nakanishi, T., Ross, D., Chen, H., Fazli, L., Gleave, M., Qiu, Y., 2008 In : Journal of Biological Chemistry. 283, 6, p. 3349-3356
Regulation of Androgen Receptor Activity by Tyrosine Phosphorylation (DOI: 10.1016/j.ccr.2006.08.021)
Guo, Z., Dai, B., Jiang, T., Xu, K., Xie, Y., Kim, O., Nesheiwat, I., Kong, X., Melamed, J., Handratta, V., Njar, V., Brodie, A., Yu, L., Veenstra, T., Chen, H., Qiu, Y., 2007 In : Cancer Cell. 11, 1, p. 97
Regulation of androgen receptor activity by tyrosine phosphorylation
Guo, Z., Dai, B., Jiang, T., Xu, K., Xie, Y., Kim, O., Nesheiwat, I., Kong, X., Melamed, J., Handratta, V., Njar, V., Brodie, A., Yu, L., Veenstra, T., Chen, H., Qiu, Y., 2006 In : Cancer Cell. 10, 4, p. 309-319
Tyrosine kinase Etk/BMX is up-regulated in human prostate cancer and its overexpression induces prostate intraepithelial neoplasia in mouse
Dai, B., Kim, O., Xie, Y., Guo, Z., Xu, K., Wang, B., Kong, X., Melamed, J., Chen, H., Bieberich, C., Borowsky, A., Kung, H., Wei, G., Ostrowski, M., Brodie, A., Qiu, Y., 2006 In : Cancer Research. 66, 16, p. 8058-8064
The 44kDa Pim-1 kinase directly interacts with tyrosine kinase Etk/BMX and protects human prostate cancer cells from apoptosis induced by chemotherapeutic drugs
Xie, Y., Xu, K., Dai, B., Guo, Z., Jiang, T., Chen, H., Qiu, Y., 2006 In : Oncogene. 25, 1, p. 70-78
Synergism of cytoplasmic kinases in IL6-induced ligand-independent activation of androgen receptor in prostate cancer cells
Kim, O., Jiang, T., Xie, Y., Guo, Z., Chen, H., Qiu, Y., 2004 In : Oncogene. 23, 10, p. 1838-1844
Targeted Disruption of the Olfactory Mucosa-Specific Cyp2g1 Gene: Impact on Acetaminophen Toxicity in the Lateral Nasal Gland, and Tissue-Selective Effects on Cyp2a5 Expression
Zhuo, X., Gu, J., Behr, M., Swiatek, P., Cui, H., Zhang, Q., Xie, Y., Collins, D., Ding, X., 2004 In : Journal of Pharmacology and Experimental Therapeutics. 308, 2, p. 719-728
Isolation and identification of a super strong plant promoter from cotton leaf curl Multan virus
Xie, Y., Liu, Y., Meng, M., Chen, L., Zhu, Z., 2003 In : Plant Molecular Biology. 53, 1-2, p. 1-14
Activation of the NPTA element of the CYP2A3 gene by NFI-A2, a nasal mucosa-selective nuclear factor 1 isoform
Xie, Y., Madelian, V., Zhang, J., Ling, G., Ding, X., 2001 In : Biochemical and Biophysical Research Communications. 289, 5, p. 1225-1228
Expressing activity of promoter elements of large intergenic region from cotton leaf curl virus in host plant
Xie, Y., Liu, Y., Zhu, Z., 2001 In : Science in China, Series C: Life Sciences. 44, 1, p. 8-17
Deletional analysis of functional regions of complementary sense promoter from cotton leaf curl virus
Xie, Y., Liu, Y., Zhu, Z., 2000 In : Science in China, Series C: Life Sciences. 43, 5, p. 505-506
Isolation of a strong promoter and its functional study
Xie, Y., Zhu, Z., Wu, Q., Xu, H., Meng, M., Liu, Y., 2000 In : Acta Botanica Sinica. 42, 1, p. 50-54
Regulatory effect of cotton leaf curl virus AC2 on virion sense promoter
Xie, Y., Zhu, Z., Wu, Q., Xu, H., Liu, Y., 2000 In : Progress in Natural Science. 10, 9, p. 678-679
Coat protein promoter from cotton leaf curl virus is not a tissue-specifically expressed promoter
Xie, Y., Zhu, Z., Liu, Y., Wu, Q., Xu, H., 2000 In : Chinese Science Bulletin. 45, 20, p. 1869-1874
Liu, G., Yang, F., Li, F., Li, Z., Lang, Y., Shen, B., Wu, Y., Li, W., Harrison, P., Strong, P., Xie, Y., Miller, K., Cao, Z., 2018 In : Frontiers in Microbiology. 9, MAY,
Re: Long-term Psychological and Quality-of-life Effects of Active Surveillance and Watchful Waiting After Diagnosis of Low-risk Localised Prostate Cancer
Ibragimova, N., Zhanzak, Z., Meyerbekova, A., Xie, Y., 2018 In : European Urology. 73, 1, p. 143-144
Dysregulation of YAP by ARF Stimulated with Tea-derived Carbon Nanodots
Xie, Y., Sun, Q., Nurkesh, A., Lu, J., Kauanova, S., Feng, J., Tursynkhan, D., Yang, Q., Kassymbek, A., Karibayev, M., Duisenova, K., Fan, H., Wang, X., Manarbek, L., Maipas, A., Chen, Z., Balanay, M., 2017 In : Scientific Reports. 7, 1,
PSA and Prostate Health Index based prostate cancer screening in a hereditary migration complicated population: Implications in precision diagnosis
Akizhanova, M., Iskakova, E., Kim, V., Wang, X., Kogay, R., Turebayeva, A., Sun, Q., Zheng, T., Wu, S., Miao, L., Xie, Y., 2017 In : Journal of Cancer. 8, 7, p. 1223-1228
SKP2 loss destabilizes EZH2 by promoting TRAF6-mediated ubiquitination to suppress prostate cancer
Lu, W., Liu, S., Li, B., Xie, Y., Izban, M., Ballard, B., Sathyanarayana, S., Adunyah, S., Matusik, R., Chen, Z., 2017 In : Oncogene. 36, 10, p. 1364-1373
Inhibition of Cancer Cell Proliferation by Carbon Dots Derived from Date Pits at Low-Dose
Xie, Y., Filchakova, O., Yang, Q., Yesbolatov, Y., Tursynkhan, D., Kassymbek, A., Bouhrara, M., Wang, K., Balanay, M., Fan, H., 2017 In : ChemistrySelect. 2, 14, p. 4079-4083
Analysis of origin and protein-protein interaction maps suggests a distinct oncogenic role of nuclear EGFR during cancer evolution
Sharip, A., Abdukhakimova, D., Wang, X., Kim, A., Kim, Y., Sharip, A., Orakov, A., Miao, L., Sun, Q., Chen, Y., Chen, Z., Xie, Y., 2017 In : Journal of Cancer. 8, 5, p. 903-912
Reverse the resistance to PARP inhibitors
Kim, Y., Kim, A., Sharip, A., Sharip, A., Jiang, J., Yang, Q., Xie, Y., 2017 In : International Journal of Biological Sciences. 13, 2, p. 198-208
Tumor Promoting Aspects of Senescence in Cancer Progression
Yang, Q., Xie, Y., Miao, L., 2016 In : Cancer Investigation. 34, 9, p. 452-458
Role of yes-associated protein in cancer: An update (Review)
Abylkassov, R., Xie, Y., 2016 In : Oncology Letters. 12, 4, p. 2277-2282
A scorpion defensin BmKDfsin4 inhibits hepatitis B virus replication in vitro
Zeng, Z., Zhang, Q., Hong, W., Xie, Y., Liu, Y., Li, W., Wu, Y., Cao, Z., 2016 In : Toxins. 8, 5,
Pim-1 kinase as cancer drug target: An update (Review)
Tursynbay, Y., Zhang, J., Li, Z., Tokay, T., Zhumadilov, Z., Wu, D., Xie, Y., 2016 In : Biomedical Reports. 4, 2, p. 140-146
MMP7 interacts with ARF in nucleus to potentiate tumor microenvironments for prostate cancer progression in vivo
Xie, Y., Lu, W., Liu, S., Yang, Q., Shawn Goodwin, J., Sathyanarayana, S., Pratap, S., Chen, Z., 2016 In : Oncotarget. 7, 30, p. 47609-47619
Identifying actionable targets through integrative analyses of GEM model and human prostate cancer genomic profiling
Wanjala, J., Taylor, B., Chapinski, C., Hieronymus, H., Wongvipat, J., Chen, Y., Nanjangud, G., Schultz, N., Xie, Y., Liu, S., Lu, W., Yang, Q., Sander, C., Chen, Z., Sawyers, C., Carver, B., 2015 In : Molecular Cancer Therapeutics. 14, 1, p. 278-288
SKP2 inactivation suppresses prostate tumorigenesis by mediating JARID1B ubiquitination
Lu, W., Liu, S., Li, B., Xie, Y., Adhiambo, C., Yang, Q., Ballard, B., Nakayama, K., Matusik, R., Chen, Z., 2015 In : Oncotarget. 6, 2, p. 771-788
Slug regulates E-cadherin repression via p19Arf in prostate tumorigenesis
Xie, Y., Liu, S., Lu, W., Yang, Q., Williams, K., Binhazim, A., Carver, B., Matusik, R., Chen, Z., 2014 In : Molecular Oncology. 8, 7, p. 1355-1364
Crosstalk between nuclear MET and SOX9/β-catenin correlates with castration-resistant prostate cancer
Xie, Y., Lu, W., Liu, S., Yang, Q., Carver, B., Li, E., Wang, Y., Fazli, L., Gleave, M., Chen, Z., 2014 In : Molecular Endocrinology. 28, 10, p. 1629-1639
Pim-1 Kinase Phosphorylates and Stabilizes 130 kDa FLT3 and Promotes Aberrant STAT5 Signaling in Acute Myeloid Leukemia with FLT3 Internal Tandem Duplication
Natarajan, K., Xie, Y., Burcu, M., Linn, D., Qiu, Y., Baer, M., 2013 In : PLoS One. 8, 9,
ARF represses androgen receptor transactivation in prostate cancer
Lu, W., Xie, Y., Ma, Y., Matusik, R., Chen, Z., 2013 In : Molecular Endocrinology. 27, 4, p. 635-648
Curcumin suppresses the growth and metastasis of prostate cancer cells by downregulation of Skp2
Gong, Y., Lu, W., Xie, Y., Yang, Q., Matusik, R., Chen, Z., 2012 Prostate Cancer Cells: Detection, Growth and Treatment. Nova Science Publishers, Inc., p. 87-102
Differential regulation of androgen receptor by P1M-1 kinases via phosphorylation-dependent recruitment of distinct ubiquitin E3 ligases
Linn, D., Yang, X., Xie, Y., Alfano, A., Deshmukh, D., Wang, X., Shimelis, H., Chen, H., Li, W., Xu, K., Chen, M., Qiu, Y., 2012 In : Journal of Biological Chemistry. 287, 27, p. 22959-22968
Inhibition of the Rho GTPase, Rac1, decreases estrogen receptor levels and is a novel therapeutic strategy in breast cancer
Rosenblatt, A., Garcia, M., Lyons, L., Xie, Y., Maiorino, C., Désiré, L., Slingerland, J., Burnstein, K., 2011 In : Endocrine-Related Cancer. 18, 2, p. 207-219
Pim-1 kinase protects P-glycoprotein from degradation and enables its glycosylation and cell surface expression
Xie, Y., Burcu, M., Linn, D., Qiu, Y., Baer, M., 2010 In : Molecular Pharmacology. 78, 2, p. 310-318
A role for OCT4 in tumor initiation of drug-resistant prostate cancer cells
Linn, D., Yang, X., Sun, F., Xie, Y., Chen, H., Jiang, R., Chen, H., Chumsri, S., Burger, A., Qiu, Y., 2010 In : Genes and Cancer. 1, 9, p. 908-916
The 44-kDa Pim-1 kinase phosphorylates BCRP/ABCG2 and thereby promotes its multimerization and drug-resistant activity in human prostate cancer cells
Xie, Y., Xu, K., Linn, D., Yang, X., Guo, Z., Shimelis, H., Nakanishi, T., Ross, D., Chen, H., Fazli, L., Gleave, M., Qiu, Y., 2008 In : Journal of Biological Chemistry. 283, 6, p. 3349-3356
Regulation of Androgen Receptor Activity by Tyrosine Phosphorylation (DOI: 10.1016/j.ccr.2006.08.021)
Guo, Z., Dai, B., Jiang, T., Xu, K., Xie, Y., Kim, O., Nesheiwat, I., Kong, X., Melamed, J., Handratta, V., Njar, V., Brodie, A., Yu, L., Veenstra, T., Chen, H., Qiu, Y., 2007 In : Cancer Cell. 11, 1, p. 97
Regulation of androgen receptor activity by tyrosine phosphorylation
Guo, Z., Dai, B., Jiang, T., Xu, K., Xie, Y., Kim, O., Nesheiwat, I., Kong, X., Melamed, J., Handratta, V., Njar, V., Brodie, A., Yu, L., Veenstra, T., Chen, H., Qiu, Y., 2006 In : Cancer Cell. 10, 4, p. 309-319
Tyrosine kinase Etk/BMX is up-regulated in human prostate cancer and its overexpression induces prostate intraepithelial neoplasia in mouse
Dai, B., Kim, O., Xie, Y., Guo, Z., Xu, K., Wang, B., Kong, X., Melamed, J., Chen, H., Bieberich, C., Borowsky, A., Kung, H., Wei, G., Ostrowski, M., Brodie, A., Qiu, Y., 2006 In : Cancer Research. 66, 16, p. 8058-8064
The 44kDa Pim-1 kinase directly interacts with tyrosine kinase Etk/BMX and protects human prostate cancer cells from apoptosis induced by chemotherapeutic drugs
Xie, Y., Xu, K., Dai, B., Guo, Z., Jiang, T., Chen, H., Qiu, Y., 2006 In : Oncogene. 25, 1, p. 70-78
Synergism of cytoplasmic kinases in IL6-induced ligand-independent activation of androgen receptor in prostate cancer cells
Kim, O., Jiang, T., Xie, Y., Guo, Z., Chen, H., Qiu, Y., 2004 In : Oncogene. 23, 10, p. 1838-1844
Targeted Disruption of the Olfactory Mucosa-Specific Cyp2g1 Gene: Impact on Acetaminophen Toxicity in the Lateral Nasal Gland, and Tissue-Selective Effects on Cyp2a5 Expression
Zhuo, X., Gu, J., Behr, M., Swiatek, P., Cui, H., Zhang, Q., Xie, Y., Collins, D., Ding, X., 2004 In : Journal of Pharmacology and Experimental Therapeutics. 308, 2, p. 719-728
Isolation and identification of a super strong plant promoter from cotton leaf curl Multan virus
Xie, Y., Liu, Y., Meng, M., Chen, L., Zhu, Z., 2003 In : Plant Molecular Biology. 53, 1-2, p. 1-14
Activation of the NPTA element of the CYP2A3 gene by NFI-A2, a nasal mucosa-selective nuclear factor 1 isoform
Xie, Y., Madelian, V., Zhang, J., Ling, G., Ding, X., 2001 In : Biochemical and Biophysical Research Communications. 289, 5, p. 1225-1228
Expressing activity of promoter elements of large intergenic region from cotton leaf curl virus in host plant
Xie, Y., Liu, Y., Zhu, Z., 2001 In : Science in China, Series C: Life Sciences. 44, 1, p. 8-17
Deletional analysis of functional regions of complementary sense promoter from cotton leaf curl virus
Xie, Y., Liu, Y., Zhu, Z., 2000 In : Science in China, Series C: Life Sciences. 43, 5, p. 505-506
Isolation of a strong promoter and its functional study
Xie, Y., Zhu, Z., Wu, Q., Xu, H., Meng, M., Liu, Y., 2000 In : Acta Botanica Sinica. 42, 1, p. 50-54
Regulatory effect of cotton leaf curl virus AC2 on virion sense promoter
Xie, Y., Zhu, Z., Wu, Q., Xu, H., Liu, Y., 2000 In : Progress in Natural Science. 10, 9, p. 678-679
Coat protein promoter from cotton leaf curl virus is not a tissue-specifically expressed promoter
Xie, Y., Zhu, Z., Liu, Y., Wu, Q., Xu, H., 2000 In : Chinese Science Bulletin. 45, 20, p. 1869-1874