Yingqiu Xie

Dr. Xie received the Ph.D. in Genetics from Institute of Genetics and Developmental Biology, Chinese Academy of Sciences. During Ph.D. studies, Dr. Xie discovered a strong promoter for bio-engineering from viral genome which was awarded a USA patent. During his postdoctoral training at University of Maryland School of Medicine, Wadsworth Center, New York State Department of Health, Meharry Medical College, USA, Dr. Xie discovered novel bio-markers of prostate cancer such as PIM-1L and nMET. In 2008, Dr. Xie was awarded a Full Professor honor of “ Mount Tai” in China. In 2015, Dr. Xie joined Nazarbayev University.  Dr. Xie has been invited as speaker in a number of international conferences. Dr. Xie has international collaborations with well-established labs in USA, and has organized student international internships. Dr. Xie has supervised postgraduate and undergraduate students to carry out cancer research and published their research results or to pass their thesis defense. Dr. Xie’s current research is focusing on molecular and biochemical mechanisms of cancer progression, signaling networks, drug targets, Nano-medicine, Nano-genomics, Gene editing, bio-engineering, clinical urological oncology and precision cancer therapeutics. Dr. Xie has many publications of original research, review, or expert opinion in top journals such as Cancer Cell, European Urology, Oncogene, JBC,  and Cancer Research. 

EDUCATION

1999 – Ph.D.,  Institute of Genetics and Developmental Biology, Chinese Academy of Sciences

RESEARCH INTERESTS  

Gene editing; Nanomedicine and nanogenomics; Signaling networks and drug target in lung cancer, prostate cancer, breast cancer and leukemia; Anti-cancer drug resistance and stem cells; Aging in cancer; Environmental health; Oncology.

Patent (inventor, not the owner):

Zhu Zhen, Xie Yingqiu, Liu Yule. CLCuV Promoter and Its Use. United States Patent Number: 6,610,907, Aug 26, 2003 (approved and awarded)

Key Publications:  (Google scholar total citations:  1172)

1. Xie Yingqiu, Filchakovaa Olena,  Qing Yang, Yerkebulan Yesbolatov, Darkhan Tursynkhan, Aishabibi Kassymbekb, Mohamed Bouhrara, Kunjie Wang, Mannix Balanay,  Haiyan Fan. Inhibition of Cancer Cell Proliferation by Carbon Dots Derived from Date Pits at Low-Dose. Chemistry Select, 2, 4079 – 4083, 2017 (SCI index)
2. Xie Yingqiu*, Aidana Mustafa, Adina Yerzhan, Dalmira Merzhakupova, Perizat Yerlan, Askarbek Orakov,  et al. Nuclear Matrix Metalloproteinases: Functions Resemble the Evolution from the Intracellular to the Extracellular Compartment. Cell Death Discovery, 2017, Aug 14;3:17036. doi: 10.1038/cddiscovery.2017.36. eCollection 2017. https://www.nature.com/cddiscovery/ (corresponding author)
3. Wenfu Lu, Shenji Liu, Bo Li, Xie Yingqiu, Michael G. Izban, Billy R. Ballard, Sandeep Anantha Sathyanarayana, Samuel E. Adunyah, Robert J. Matusik, and Zhenbang Chen. SKP2 loss destabilizes EZH2 by promoting TRAF6-mediated ubiquitination to suppress prostate cancer. Oncogene, 36 (10), 1364-1373, 2017. (SCI, IF 7.932)
4. Wanjala Jackie, Barry Taylor, Caren Chapinski, Haley Hieronymus, John Wongvipat, Yu Chen, Gouri J Nanjangud, Nikolaus Schultz, Xie Yingqiu, Shenji Liu, Wenfu Lu, Qing Yang, Chris Sander, Chen Zhenbang, Sawyers L Charles, and Carver Brett S, Identifying Actionable Targets through Integrative Analyses of GEM Model and Human Prostate Cancer Genomic Profiling. Molecular Cancer Therapeutics, 14(1), 278-88. 2015  ( IF 5.863)
5. Xie Yingqiu, Lu Wenfu, Liu Shenji, Yang Qing, Williams Kieosha, Carver Brett S, Matusik Robert J, and Chen Zhenbang. Slug regulates E-cadherin repression via p19Arf in prostate tumorigenesis. Molecular Oncology, 8(7), 1355-1364, 2014  
6. Xie Yingqiu, Liu Shenji, Lu Wenfu, Yang Qing, Carver Brett S, Li Estelle, Wang Yuzhuo, Fazli Ladan, Gleave Martin and Chen Zhenbang. Crosstalk between Nuclear MET and SOX9/β-Catenin Correlates with Castration Resistant Prostate Cancer. Molecular Endocrinology, 28(10),1629-1639, 2014.  
7. Natarajan Karthika, Xie Yingqiu, Burcu Mehmet, Linn Douglas, Qiu Yun, Baer Maria. Pim-1 kinase phosphorylates and stabilizes 130 kDa FLT3 and promotes aberrant STAT5 signaling in acute myeloid leukemia with FLT3 internal tandem duplication. PLoS One. Sep 5;8(9), e74653, 2013.
8. Lu Wenfu, Xie Yingqiu, Ma Yu, Matusik Robert J, Chen Zhenbang. ARF represses androgen receptor transactivation in prostate cancer. Molecular Endocrinology, 27(4), 635-648, 2013.
9. Linn Douglas, Yang Xi, Xie Yingqiu, Alfano Alan, Deshmukh Dhanraj, Wang Xin, Shimelis Hermela, Chen Hegang, Li Wei, Xu Kexin, Chen Mingyuan and Qiu Yun. Differential regulation of androgen receptor by PIM-1 kinases via phosphorylation-dependent recruitment of distinct ubiquitin E3 ligases. Journal of Biological Chemistry, 287(27), 22959-22968, 2012. 
10. Xie Yingqiu, Burcu Mehmet, Linn Douglas, Qiu Yun, Baer Maria. Pim-1 kinase protects P-glycoprotein from degradation and enables its glycosylation and cell surface expression. Molecular Pharmacology, 78(2), 310-318, 2010.
11. Xie Yingqiu, Xu Kexin, Linn Douglas, Guo Zhiyong, Hermela Shimelis Nakanishi Takeo, Ross Douglas D., Chen Hegang, Fazli Ladan, Gleave Martin E. and Qiu Yun. The 44 kDa Pim-1 kinase phosphorylates BCRP/ABCG2 and thereby promotes its multimerization and drug resistant activity in human prostate cancer cells. Journal of Biological Chemistry, 283, 3349-3356, 2008.
12. Xie Yingqiu, Xu Kexin, Dai Bojie, Guo Zhiyong, Jiang Tianyun, Chen hegang and Qiu Yun. The 44 kDa Pim-1 kinase directly interacts with tyrosine kinase Etk/BMX and protects human prostate cancer cells from apoptosis induced by chemotherapeutic drugs. Oncogene, 25, 70-78, 2006.
13. Guo Zhiyong, Dai Bojie, Jiang Tianyun, Xu Kexin, Xie Yingqiu, Kim Oekyung et al. and Qiu Yun. Regulation of androgen receptor activity by tyrosine phosphorylation. Cancer Cell, 10, 309-319, 2006.
14. Dai Bojie, Kim Oekyung, Xie Yingqiu, Guo Zhiyong, Xu Kexin, Bin Wang, Xiangtian Kong, Melamed Jonathan, Chen Hegang, Bieberich Charles J., Borowsky Alexander D., Kung Hsing-Jien, Wei Guo, Ostrowski Michael C., Brodie Angela, and Qiu Yun. Tyrosine kinase Etk/BMX is up-regulated in human prostate cancer and its overexpression induces prostate intraepithelial neoplasia in mouse. Cancer Research. 66, 8058-8064, 2006.
15. Kim Oekyung, Jiang Tianyun, Xie Yingqiu, Guo Zhiyong, Chen hegang, Qiu Yun. Synergism of cytoplasmic kinases in IL-6-induced ligand-independent activation of androgen receptor in prostate cancer cells. Oncogene, 23, 1838-1844, 2004.
16. Xie Yingqiu, Liu Yule, Meng Meng, Chen Lei, Zhu Zhen. Isolation and identification of a super strong plant promoter from cotton leaf curl Multan virus. Plant Molecular Biology, 53(1-2), 1-14, 2003.
17. Xie Yingqiu, Madelian Vergine, Zhang Jianhua, Ling Guoyu, Ding Xinxin. Activation of the NPTA element of the rat CYP2A3 gene by NF1-A2, a nasal mucosa-selective nuclear factor I isoform. Biochemical and Biophysical Research Communications, 289(5), 1225-1228, 2001.

 

Therapeutic potential of a scorpion venom-derived antimicrobial peptide and its homologs against antibiotic-resistant Gram-positive bacteria
Liu, G., Yang, F., Li, F., Li, Z., Lang, Y., Shen, B., Wu, Y., Li, W., Harrison, P., Strong, P., Xie, Y., Miller, K., Cao, Z., 2018 In : Frontiers in Microbiology. 9, MAY,

Re: Long-term Psychological and Quality-of-life Effects of Active Surveillance and Watchful Waiting After Diagnosis of Low-risk Localised Prostate Cancer
Ibragimova, N., Zhanzak, Z., Meyerbekova, A., Xie, Y., 2018 In : European Urology. 73, 1, p. 143-144

Dysregulation of YAP by ARF Stimulated with Tea-derived Carbon Nanodots
Xie, Y., Sun, Q., Nurkesh, A., Lu, J., Kauanova, S., Feng, J., Tursynkhan, D., Yang, Q., Kassymbek, A., Karibayev, M., Duisenova, K., Fan, H., Wang, X., Manarbek, L., Maipas, A., Chen, Z., Balanay, M., 2017 In : Scientific Reports. 7, 1,

PSA and Prostate Health Index based prostate cancer screening in a hereditary migration complicated population: Implications in precision diagnosis
Akizhanova, M., Iskakova, E., Kim, V., Wang, X., Kogay, R., Turebayeva, A., Sun, Q., Zheng, T., Wu, S., Miao, L., Xie, Y., 2017 In : Journal of Cancer. 8, 7, p. 1223-1228

SKP2 loss destabilizes EZH2 by promoting TRAF6-mediated ubiquitination to suppress prostate cancer
Lu, W., Liu, S., Li, B., Xie, Y., Izban, M., Ballard, B., Sathyanarayana, S., Adunyah, S., Matusik, R., Chen, Z., 2017 In : Oncogene. 36, 10, p. 1364-1373

Inhibition of Cancer Cell Proliferation by Carbon Dots Derived from Date Pits at Low-Dose
Xie, Y., Filchakova, O., Yang, Q., Yesbolatov, Y., Tursynkhan, D., Kassymbek, A., Bouhrara, M., Wang, K., Balanay, M., Fan, H., 2017 In : ChemistrySelect. 2, 14, p. 4079-4083

Analysis of origin and protein-protein interaction maps suggests a distinct oncogenic role of nuclear EGFR during cancer evolution
Sharip, A., Abdukhakimova, D., Wang, X., Kim, A., Kim, Y., Sharip, A., Orakov, A., Miao, L., Sun, Q., Chen, Y., Chen, Z., Xie, Y., 2017 In : Journal of Cancer. 8, 5, p. 903-912

Reverse the resistance to PARP inhibitors
Kim, Y., Kim, A., Sharip, A., Sharip, A., Jiang, J., Yang, Q., Xie, Y., 2017 In : International Journal of Biological Sciences. 13, 2, p. 198-208

Tumor Promoting Aspects of Senescence in Cancer Progression
Yang, Q., Xie, Y., Miao, L., 2016 In : Cancer Investigation. 34, 9, p. 452-458

Role of yes-associated protein in cancer: An update (Review)
Abylkassov, R., Xie, Y., 2016 In : Oncology Letters. 12, 4, p. 2277-2282

A scorpion defensin BmKDfsin4 inhibits hepatitis B virus replication in vitro
Zeng, Z., Zhang, Q., Hong, W., Xie, Y., Liu, Y., Li, W., Wu, Y., Cao, Z., 2016 In : Toxins. 8, 5,

Pim-1 kinase as cancer drug target: An update (Review)
Tursynbay, Y., Zhang, J., Li, Z., Tokay, T., Zhumadilov, Z., Wu, D., Xie, Y., 2016 In : Biomedical Reports. 4, 2, p. 140-146

MMP7 interacts with ARF in nucleus to potentiate tumor microenvironments for prostate cancer progression in vivo
Xie, Y., Lu, W., Liu, S., Yang, Q., Shawn Goodwin, J., Sathyanarayana, S., Pratap, S., Chen, Z., 2016 In : Oncotarget. 7, 30, p. 47609-47619

Identifying actionable targets through integrative analyses of GEM model and human prostate cancer genomic profiling
Wanjala, J., Taylor, B., Chapinski, C., Hieronymus, H., Wongvipat, J., Chen, Y., Nanjangud, G., Schultz, N., Xie, Y., Liu, S., Lu, W., Yang, Q., Sander, C., Chen, Z., Sawyers, C., Carver, B., 2015 In : Molecular Cancer Therapeutics. 14, 1, p. 278-288

SKP2 inactivation suppresses prostate tumorigenesis by mediating JARID1B ubiquitination
Lu, W., Liu, S., Li, B., Xie, Y., Adhiambo, C., Yang, Q., Ballard, B., Nakayama, K., Matusik, R., Chen, Z., 2015 In : Oncotarget. 6, 2, p. 771-788

Slug regulates E-cadherin repression via p19Arf in prostate tumorigenesis
Xie, Y., Liu, S., Lu, W., Yang, Q., Williams, K., Binhazim, A., Carver, B., Matusik, R., Chen, Z., 2014 In : Molecular Oncology. 8, 7, p. 1355-1364

Crosstalk between nuclear MET and SOX9/β-catenin correlates with castration-resistant prostate cancer
Xie, Y., Lu, W., Liu, S., Yang, Q., Carver, B., Li, E., Wang, Y., Fazli, L., Gleave, M., Chen, Z., 2014 In : Molecular Endocrinology. 28, 10, p. 1629-1639

Pim-1 Kinase Phosphorylates and Stabilizes 130 kDa FLT3 and Promotes Aberrant STAT5 Signaling in Acute Myeloid Leukemia with FLT3 Internal Tandem Duplication
Natarajan, K., Xie, Y., Burcu, M., Linn, D., Qiu, Y., Baer, M., 2013 In : PLoS One. 8, 9,

ARF represses androgen receptor transactivation in prostate cancer
Lu, W., Xie, Y., Ma, Y., Matusik, R., Chen, Z., 2013 In : Molecular Endocrinology. 27, 4, p. 635-648

Curcumin suppresses the growth and metastasis of prostate cancer cells by downregulation of Skp2
Gong, Y., Lu, W., Xie, Y., Yang, Q., Matusik, R., Chen, Z., 2012 Prostate Cancer Cells: Detection, Growth and Treatment. Nova Science Publishers, Inc., p. 87-102

Differential regulation of androgen receptor by P1M-1 kinases via phosphorylation-dependent recruitment of distinct ubiquitin E3 ligases
Linn, D., Yang, X., Xie, Y., Alfano, A., Deshmukh, D., Wang, X., Shimelis, H., Chen, H., Li, W., Xu, K., Chen, M., Qiu, Y., 2012 In : Journal of Biological Chemistry. 287, 27, p. 22959-22968

Inhibition of the Rho GTPase, Rac1, decreases estrogen receptor levels and is a novel therapeutic strategy in breast cancer
Rosenblatt, A., Garcia, M., Lyons, L., Xie, Y., Maiorino, C., Désiré, L., Slingerland, J., Burnstein, K., 2011 In : Endocrine-Related Cancer. 18, 2, p. 207-219

Pim-1 kinase protects P-glycoprotein from degradation and enables its glycosylation and cell surface expression
Xie, Y., Burcu, M., Linn, D., Qiu, Y., Baer, M., 2010 In : Molecular Pharmacology. 78, 2, p. 310-318

A role for OCT4 in tumor initiation of drug-resistant prostate cancer cells
Linn, D., Yang, X., Sun, F., Xie, Y., Chen, H., Jiang, R., Chen, H., Chumsri, S., Burger, A., Qiu, Y., 2010 In : Genes and Cancer. 1, 9, p. 908-916

The 44-kDa Pim-1 kinase phosphorylates BCRP/ABCG2 and thereby promotes its multimerization and drug-resistant activity in human prostate cancer cells
Xie, Y., Xu, K., Linn, D., Yang, X., Guo, Z., Shimelis, H., Nakanishi, T., Ross, D., Chen, H., Fazli, L., Gleave, M., Qiu, Y., 2008 In : Journal of Biological Chemistry. 283, 6, p. 3349-3356

Regulation of Androgen Receptor Activity by Tyrosine Phosphorylation (DOI: 10.1016/j.ccr.2006.08.021)
Guo, Z., Dai, B., Jiang, T., Xu, K., Xie, Y., Kim, O., Nesheiwat, I., Kong, X., Melamed, J., Handratta, V., Njar, V., Brodie, A., Yu, L., Veenstra, T., Chen, H., Qiu, Y., 2007 In : Cancer Cell. 11, 1, p. 97

Regulation of androgen receptor activity by tyrosine phosphorylation
Guo, Z., Dai, B., Jiang, T., Xu, K., Xie, Y., Kim, O., Nesheiwat, I., Kong, X., Melamed, J., Handratta, V., Njar, V., Brodie, A., Yu, L., Veenstra, T., Chen, H., Qiu, Y., 2006 In : Cancer Cell. 10, 4, p. 309-319

Tyrosine kinase Etk/BMX is up-regulated in human prostate cancer and its overexpression induces prostate intraepithelial neoplasia in mouse
Dai, B., Kim, O., Xie, Y., Guo, Z., Xu, K., Wang, B., Kong, X., Melamed, J., Chen, H., Bieberich, C., Borowsky, A., Kung, H., Wei, G., Ostrowski, M., Brodie, A., Qiu, Y., 2006 In : Cancer Research. 66, 16, p. 8058-8064

The 44kDa Pim-1 kinase directly interacts with tyrosine kinase Etk/BMX and protects human prostate cancer cells from apoptosis induced by chemotherapeutic drugs
Xie, Y., Xu, K., Dai, B., Guo, Z., Jiang, T., Chen, H., Qiu, Y., 2006 In : Oncogene. 25, 1, p. 70-78

Synergism of cytoplasmic kinases in IL6-induced ligand-independent activation of androgen receptor in prostate cancer cells
Kim, O., Jiang, T., Xie, Y., Guo, Z., Chen, H., Qiu, Y., 2004 In : Oncogene. 23, 10, p. 1838-1844

Targeted Disruption of the Olfactory Mucosa-Specific Cyp2g1 Gene: Impact on Acetaminophen Toxicity in the Lateral Nasal Gland, and Tissue-Selective Effects on Cyp2a5 Expression
Zhuo, X., Gu, J., Behr, M., Swiatek, P., Cui, H., Zhang, Q., Xie, Y., Collins, D., Ding, X., 2004 In : Journal of Pharmacology and Experimental Therapeutics. 308, 2, p. 719-728

Isolation and identification of a super strong plant promoter from cotton leaf curl Multan virus
Xie, Y., Liu, Y., Meng, M., Chen, L., Zhu, Z., 2003 In : Plant Molecular Biology. 53, 1-2, p. 1-14

Activation of the NPTA element of the CYP2A3 gene by NFI-A2, a nasal mucosa-selective nuclear factor 1 isoform
Xie, Y., Madelian, V., Zhang, J., Ling, G., Ding, X., 2001 In : Biochemical and Biophysical Research Communications. 289, 5, p. 1225-1228

Expressing activity of promoter elements of large intergenic region from cotton leaf curl virus in host plant
Xie, Y., Liu, Y., Zhu, Z., 2001 In : Science in China, Series C: Life Sciences. 44, 1, p. 8-17

Deletional analysis of functional regions of complementary sense promoter from cotton leaf curl virus
Xie, Y., Liu, Y., Zhu, Z., 2000 In : Science in China, Series C: Life Sciences. 43, 5, p. 505-506

Isolation of a strong promoter and its functional study
Xie, Y., Zhu, Z., Wu, Q., Xu, H., Meng, M., Liu, Y., 2000 In : Acta Botanica Sinica. 42, 1, p. 50-54

Regulatory effect of cotton leaf curl virus AC2 on virion sense promoter
Xie, Y., Zhu, Z., Wu, Q., Xu, H., Liu, Y., 2000 In : Progress in Natural Science. 10, 9, p. 678-679

Coat protein promoter from cotton leaf curl virus is not a tissue-specifically expressed promoter
Xie, Y., Zhu, Z., Liu, Y., Wu, Q., Xu, H., 2000 In : Chinese Science Bulletin. 45, 20, p. 1869-1874