Ferdinand Molnár
Department
School of Sciences and Humanities, Biology Title
Associate professor Office
7e519 Email
ferdinand.molnar@old.nu.edu.kzEducation:
> 2008 Dipl. Ing. Management, Slovak Technical University (SK)
> 2006 Ph.D. Biochemistry, University of Kuopio (FI)
> 2001 M.Sc. Biochemistry, Comenius University (SK)
Area of Expertise:
Structural biology and bioinformatics, Protein complexes, Nuclear receptors, Transcriptional regulation, Recombinant protein expression and purification, Biopharmaceuticals
Teaching – Lectures (Courses Offered):
- BIOL 110 Modern Biology I
- BIOL 341 Biochemistry
- BIOL 363 Structural Bioinformatics
- BIOL 631 Synthetic Biology
- BIOL 632 Drug Discovery and Design
- BIOL 635 Hot Topics in Life Sciences
Published textbooks:
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2020
Burster Timo, Knippschild Uwe, Molnár Ferdinand, Zhanapiya Anuar (2020) Cathepsin G and its dichotomous role in modulating levels of MHC class I molecules. Arch Immunol Ther Exp (Warsz)68, 25 doi: 10.1007/s00005-020-00585-3 (IF2018/2019 2.9 Journal link
(1.6MB) 2019
Maestro A. Miguel, Molnár Ferdinand & Carlberg Carsten (2019) Vitamin D and its synthetic analogs. J. Med. Chem.62, 6854-6875 doi: 10.1021/acs.jmedchem.9b00208 (IF2018/2019 6.1 Journal link
(8.4MB) Supporting information (12.2MB) Touloupi Katerina, Küblbeck Jenni, Magklara Angeliki, Molnár Ferdinand, Reinisalo Mika, Konstandi Maria, Honkakoski Paavo & Pappas Periklis (2019) The basis for strain-dependent rat aldehyde dehydrogenase 1A7 (ALDH1A7) gene expression. Mol. Pharmacol. 96, 655-663 (IF2018/2019 3.9 Journal link
(726KB) 2018
Prantner Viktória, Cinnamon Yuval, Küblbeck Jenni, Molnár Ferdinand & Honkakoski Paavo (2018) Characterization of a novel functional variant in nuclear receptor CAR (NR1I3). Nucl. Receptor Res. 5 doi:10.32527/2018/101386 Journal link
(1.9MB) 2017
Rochel Natacha & Molnár Ferdinand (2017) Structural aspects of Vitamin D endocrinology. Mol. Cell. Endocrinol. 453, 22-35 doi: 10.1016/j.mce.2017.02.046 (IF2017 3.6) Journal link
(3.4MB) 2016
Peters H. Björn, Staels Lotte, Rantanen Jimi, Molnár Ferdinand, DeBeer Thomas, Lehto Vesa-Pekka, & Ketolainen Jarko (2016) Effects of Cooling Rate in Micro- and Pilot Scale Freeze-Drying - Variations in Excipient Polymorphs and Protein Secondary Structure. Eur. J. Pharm. Sci. 95, 72-81 doi: 10.1016/j.ejps.2016.05.020 (IF2016 3.8) Journal link
(1.9MB) Küblbeck Jenni, Zancanella Vanessa, Prantner Viktória, Molnár Ferdinand, Squires E. James, Dacasto Mauro, Honkakoski Paavo & Giantin Mery (2016) Characterization of ligand-dependent activation of bovine and pig constitutive androstane (CAR) and pregnane X receptors (PXR) with interspecies comparisons. Xenobiotica 46, 200-210 (IF2016 1.6) Journal link
(702KB) Maestro Miguel *, Molnár Ferdinand *, Mouriño Antonio, Carlberg Carsten (2016) Vitamin D receptor 2016: novel ligands and structural insights. Expert. Opin. Ther. Pat. 26, 1291-1306 (IF2016 3.0) Journal link
(5.1MB) 2015
Peters H. Björn, Leskinen T.T. Jari, Molnár Ferdinand & Ketolainen Jarko (2015) Impact of microscale and pilot scale freeze-drying on protein secondary structures: Local variations of lysozyme and catalase. J. Pharm. Sci. 104, 3710-3721 doi: 10.1002/jps.24615 (IF2015 2.6) Journal link
(1.3MB) Huet Tiphaine, Laverny Gilles, Fabrice Ciesielski, Molnár Ferdinand, Ramamoorthy Thanuja Gali, Belorusova Y. Anna, Antony Pierre, Potier Noelle, Metzger Daniel, Moras Dino & Rochel Natacha (2015) Temporal control of Vitamin D receptor (VDR) mediated signaling in mice expressing a structure-based point-mutated VDR. Cell Rep. 10, 516-526 (IF2015 7.9) Journal link
(1.4MB) Supporting information (749KB) Carlberg Carsten & Molnár Ferdinand (2015) Vitamin D signaling and its therapeutic implications. Can. J. Physiol. Pharmacol. 93, 311-318 (IF2015 1.7) Journal link
(3.3MB) 2014
Molnár Ferdinand (2014) Structural considerations of vitamin D signaling. Front. Physiol. 5, 191 doi: 10.3389/fphys.2014.00191 (IF2014 3.5) Journal link
(6.5MB) Kokkola Tarja, Suuronen Tiina, Molnár Ferdinand, Määttä Juha, Salminen Antero, Jarho M. Elina & Lahtela-Kakkonen Maija (2014) AROS has a context-dependent effect on SIRT1. FEBS Lett. 588, 1523-1528 (IF2014 3.2) Journal link
(737KB)Peters H. Björn, Molnár Ferdinand & Ketolainen Jarko (2014) Structural attributes of model protein formulations prepared by rapid freeze-drying cycles in a microscale heating stage. Eur. J. Pharm. Biopharm. 87, 347-356 (IF2014 3.9) Journal link
(1.8MB)2013
Molnár Ferdinand, Küblbeck Jenni, Prantner Viktória & Honkakoski Paavo (2013) An update on the constitutive androstane receptor CAR. Drug Metab. Drug Interact. 13, 1-15 (IF2013 3.5) Journal link
(544KB) 2012
Carlberg Carsten, Molnár Ferdinand, & Mouriño Antonio (2012) Vitamin D receptor ligands: The impact of crystal structures. Expert Opin. Ther. Pat. 22, 417-435 (IF2012 3.5) Journal link
(4.6MB) Carlberg Carsten & Molnár Ferdinand (2012) Current status of vitamin D signaling and its therapeutic applications. Curr. Topics Med. Chem. 12, 528-547 (IF2012 3.7) Journal link
(4.8MB) Fraga Ramón, Zacconi Flavia, Sussman Fredy, Ordóñez-Morán Paloma, Muñoz Alberto, Huet Tiphaine, Molnár Ferdinand, Moras Dino, Rochel Natacha, Maestro Miguel & Mouriño Antonio (2011) Design, Synthesis, Evaluation and Structure of Vitamin D Analogues with Furan Side Chains. Chem.–Eur. J. 18, 603-12 (IF2012 5.8) Journal link
(1.2MB) 2011
Küblbeck Jenni, Jyrkkärinne Johanna, Molnár Ferdinand, Kuningas Tiina, Patel Jayendra, Windshügel Björn, Nevalainen Tapio, Laitinen Tuomo, Sippl Wolfgang, Poso Antti & Honkakoski Paavo (2011) New in vitro tools to study human CAR biology: Discovery and comparison of human CAR inverse agonists. Mol. Pharmaceutics 8, 2424-33 (IF2011 4.8) Journal link
(2.3MB) Küblbeck Jenni, Laitinen Tuomo, Jyrkkärinne Johanna, Rousu Timo, Tolonen Ari, Abel Tobias, Kortelainen Tanja, Uusitalo Jouko, Korjamo Timo, Honkakoski Paavo & Molnár Ferdinand (2011) Use of comprehensive screening methods to detect selective human CAR activators. Biochem. Phamacol. 82, 1994-2007 (IF2011 4.7) Journal link
(1.9MB) Molnár Ferdinand, Sigüeiro Rita, Yoshiteru Sato, Araujo Clarisse, Schuster Inge, Antony Pierre, Peluso Jean, Muller Christian, Mouriño Antonio, Moras Dino & Rochel Natacha (2011) 1α,25-dihydroxy-3-epi-vitamin D3, a natural physiological metabolite of vitamin D3: its synthesis, biological activity and crystal structure with its receptor. PLOS One 6 (3), e18124. doi:10.1371/journal.pone.0018124 (IF2011 4.1) Journal link
(560KB) Supporting information (7.8MB)2010
Yan-Ru Lou, Molnár Ferdinand, Peräkylä Mikael, Shengjun Qiao, Allan V. Kalueff, René St-Arnaud, Carlberg Carsten & Tuohimaa Pentti (2010) 25-Hydroxyvitamin D3 is an agonistic vitamin D receptor ligand. J. Steroid Biochem. Mol. Biol. 118, 162-170 (IF2010 2.9) Journal link
(728KB)Venäläinen Tuomas, Molnár Ferdinand, Oostenbrink Chris, Carlberg Carsten & Peräkylä Mikael (2010) Molecular mechanism of allosteric communication in the PPARα-RXRα heterodimer. Proteins: Structure, Function, and Bioinformatics. 78, 873-87 (IF2010 2.8) Journal link
(1.5MB)2006
Carlberg Carsten & Molnár Ferdinand (2006) Detailed molecular understanding of agonistic and antagonistic vitamin D receptor ligands. Curr. Topics Med. Chem. 6, 1243-1253 (IF2006 4.2) Journal link
(241KB)Molnár Ferdinand, Peräkylä Mikael & Carlberg Carsten (2006) Vitamin D receptor agonists specifically modulate the volume of the ligand-binding pocket. J. Biol Chem. 281, 10516-10526 (IF2006 5.8) Journal link
(1.4MB)2005
Molnár Ferdinand, Matilainen Merja & Carlberg Carsten (2005) Structural Determinants of the Agonist-independent Association of Human Peroxisome Proliferator-activated Receptors with Coactivators. J. Biol Chem. 280, 26543-26556 (IF2005 5.9) Journal link
(1.3MB)Lempiäinen Harri, Molnár Ferdinand, Macias-Gonzalez Manuel, Peräkylä Mikael & Carlberg Carsten (2005) Antagonist- and inverse agonist-driven interactions of the vitamin D receptor and the constitutive androstane receptor with co-repressor protein. Mol. Endocrinol. 19, 2258-2272 (IF2005 5.8) Journal link
(701KB)Dunlop W. Thomas, Väisänen Sami, Frank Christian, Molnár Ferdinand, Sinkkonen Lasse & Carlberg Carsten (2005) The human peroxisome proliferator-activated receptor δ gene is a primary target of 1α,25-dihydroxyvitamin D3 and its nuclear receptor. J. Mol. Biol. 349, 248-360 (IF2005 5.2) Journal link
(532KB)2004
Peräkylä Mikael *, Molnár Ferdinand* & Carlberg Carsten (2004) Structural basis for the species-specific antagonism of 26,23 lactones on vitamin D signaling. Chem. & Biol. 11, 1147-1156 (IF2004 5.7) Journal link
(558KB)Frank Christian, Molnár Ferdinand, Matilainen Merja, Lempiäinen Harri & Carlberg Carsten (2004) Agonist-dependent and -independent transactivation of the human constitutive androstane receptor are modulated by specific amino acid pairs. J. Biol. Chem. 279, 33558-33566 (IF2004 6.4) Journal link
(556KB)* equally contributed authorship