Гонзало Хортелано
Департамент
Жаратылыстану, әлеуметтік және гуманитарлық мектебі, Биология, National Laboratory Astana, Laboratory of bioinformatics and computational systems biology, Immunobiology Laboratory Лауазымы
Декан міндетін атқарушы Кеңсе
7232 Электр. пошта
gonzalo.hortelano@old.nu.edu.kz Телефон
5782 Fibronectin-Alginate microcapsules improve cell viability and protein secretion of encapsulated Factor IX-engineered human mesenchymal stromal cells
Sayyar, B., Dodd, M., Marquez-Curtis, L., Janowska-Wieczorek, A., Hortelano, G., 2015 In : Artificial Cells, Nanomedicine and Biotechnology. 43, 5, p. 318-327
Sustained expression of coagulation factor IX by modified cord blood-derived mesenchymal stromal cells
Dodd, M., Marquez-Curtis, L., Janowska-Wieczorek, A., Hortelano, G., 2014 In : Journal of Gene Medicine. 16, 5-6, p. 131-142
Cell-matrix Interactions of Factor IX (FIX)-engineered human mesenchymal stromal cells encapsulated in RGD-alginate vs. Fibrinogen-alginate microcapsules
Sayyar, B., Dodd, M., Marquez-Curtis, L., Janowska-Wieczorek, A., Hortelano, G., 2014 In : Artificial Cells, Nanomedicine and Biotechnology. 42, 2, p. 102-109
Strategies for ocular siRNA delivery: Potential and limitations of non-viral nanocarriers
Thakur, A., Fitzpatrick, S., Zaman, A., Kugathasan, K., Muirhead, B., Hortelano, G., Sheardown, H., 2012 In : Journal of Biological Engineering. 6,
Encapsulated engineered myoblasts can cure Hurler syndrome: Preclinical experiments in the mouse model
Piller Puicher, E., Tomanin, R., Salvalaio, M., Friso, A., Hortelano, G., Marin, O., Scarpa, M., 2012 In : Gene Therapy. 19, 4, p. 355-364
Single-colour flow cytometric assay to determine NK cell-mediated cytotoxicity and viability against non-adherent human tumor cells
Thakur, A., Zaman, A., Hummel, J., Jones, K., Hortelano, G., 2012 In : Biotechnology Letters. 34, 3, p. 447-453
Encapsulation of factor IX-engineered mesenchymal stem cells in fibrinogen-alginate microcapsules enhances their viability and transgene secretion
Sayyar, B., Dodd, M., Wen, J., Ma, S., Marquez-Curtis, L., Janowska-Wieczorek, A., Hortelano, G., 2012 In : Journal of Tissue Engineering. 3, 1, p. 1-12
Repeated oral administration of chitosan/DNA nanoparticles delivers functional FVIII with the absence of antibodies in hemophilia A mice
Dhadwar, S., Kiernan, J., Wen, J., Hortelano, G., 2010 In : Journal of Thrombosis and Haemostasis. 8, 12, p. 2743-2750
Monkey business for hemophilia management
Hortelano, G., 2010 In : Thrombosis Research. 126, 5, p. 365-366
Therapeutic applications of cell microencapsulation. Foreword.
Hortelano, G., 2010 In : Advances in Experimental Medicine and Biology. 670,
Characterization of viability and proliferation of alginate-poly-L-lysine- alginate encapsulated myoblasts using flow cytometry
Thakur, A., Sengupta, R., Matsui, H., Lillicrap, D., Jones, K., Hortelano, G., 2010 In : Journal of Biomedical Materials Research - Part B Applied Biomaterials. 94, 2, p. 296-304
Advances in Experimental Medicine and Biology: Foreword
Hortelano, G., 2010 In : Advances in Experimental Medicine and Biology. 670,
Early intraplatelet signaling enhances the release of human platelet PAR-1 and -4 amino-terminal peptides in response to thrombin
Ofosu, F., Dewar, L., Song, Y., Cedrone, A., Hortelano, G., Craven, S., 2009 In : Biochemistry. 48, 7, p. 1562-1572
Factors that contribute to the immmunogenicity of therapeutic recombinant human proteins
Mukovozov, I., Sabljic, T., Hortelano, G., Ofosu, F., 2008 In : Thrombosis and Haemostasis. 99, 5, p. 874-882
Encapsulated human primary myoblasts deliver functional hFIX in hemophilic mice
Wen, J., Xu, N., Li, A., Bourgeois, J., Ofosu, F., Hortelano, G., 2007 In : Journal of Gene Medicine. 9, 11, p. 1002-1010
Transplants for Hemophilia
Gómez-Vargas, A., Hortelano, G., 2007 Cellular Transplantation. Elsevier, p. 187-203
Sustained and therapeutic levels of human factor IX in hemophilia B mice implanted with microcapsules: Key role of encapsulated cells
Wen, J., Vargas, A., Ofosu, F., Hortelano, G., 2006 In : Journal of Gene Medicine. 8, 3, p. 362-369
An important role for the activation peptide domain in controlling factor IX levels in the blood of haemophilia B mice
Begbie, M., Mamdani, A., Gataiance, S., Eltringham-Smith, L., Bhakta, V., Hortelano, G., Sheffield, W., 2005 In : Thrombosis and Haemostasis. 94, 6, p. 1138-1147
Reduction of GAG storage in MPS II mouse model following implantation on encapsulated recombinant myoblasts
Friso, A., Tomanin, R., Alba, S., Gasparotto, N., Puicher, E., Fusco, M., Hortelano, G., Muenzer, J., Marin, O., Zacchello, F., Scarpa, M., 2005 In : Journal of Gene Medicine. 7, 11, p. 1482-1491
Continuous antigenic stimulation system (CASS) as a new immunization strategy
Gomez-Vargas, A., Rosenthal, K., McDermott, M., Hortelano, G., 2004 In : Vaccine. 22, 29-30, p. 3902-3910
Effects of genetic fusion of factor IX to albumin on in vivo clearance in mice and rabbits
Sheffield, W., Mamdani, A., Hortelano, G., Gataiance, S., Eltringham-Smith, L., Begbie, M., Leyva, R., Liaw, P., Ofosu, F., 2004 In : British Journal of Haematology. 126, 4, p. 565-573
Nonviral gene therapy approaches to hemophilia
Gómez-Vargas, A., Hortelano, G., 2004 In : Seminars in Thrombosis and Hemostasis. 30, 2, p. 197-204
History, challenges and perspectives of cell microencapsulation
Orive, G., Hernández, R., Rodríguez Gascón, A., Calafiore, R., Chang, T., De Vos, P., Hortelano, G., Hunkeler, D., Lacík, I., Pedraz, J., 2004 In : Trends in Biotechnology. 22, 2, p. 87-92
Cell encapsulation: Promise and progress
Orive, G., Hernández, R., Gascón, A., Calafiore, R., Chang, T., De Vos, P., Hortelano, G., Hunkeler, D., Lacík, I., Shapiro, A., Pedraz, J., 2003 In : Nature Medicine. 9, 1, p. 104-107
Polymer-encapsulated engineered adult mesenchymal stem cells secrete exogenously regulated rhBMP-2, and induce osteogenic and angiogenic tissue formation
Zilberman, Y., Turgeman, G., Pelled, G., Xu, N., Moutsatsos, I., Hortelano, G., Gazit, D., 2002 In : Polymers for Advanced Technologies. 13, 10-12, p. 863-870
Therapeutic levels of human Factor VIII in mice implanted with encapsulated cells: Potential for gene therapy of haemophilia A
García-Martín, C., Chuah, M., Van Damme, A., Robinson, K., Vanzieleghem, B., Saint-Remy, J., Gallardo, D., Ofosu, F., Vandendriessche, T., Hortelano, G., 2002 In : Journal of Gene Medicine. 4, 2, p. 215-223
Non-viral transfer approaches for the gene therapy of mucopolysaccharidosis type II (Hunter syndrome)
Tomanin, R., Friso, A., Alba, S., Piller Puicher, E., Mennuni, C., La Monica, N., Hortelano, G., Zacchello, F., Scarpa, M., 2002 In : Acta Paediatrica, International Journal of Paediatrics, Supplement. 91, 439, p. 100-104
Sustained and therapeutic delivery of factor IX in nude haemophilia B mice by encapsulated C2C12 myoblasts: Concurrent tumourigenesis
Hortelano, G., Wang, L., Xu, N., Ofosu, F., 2001 In : Haemophilia. 7, 2, p. 207-214
Gene therapy for hemophilia
Hortelano, G., Chang, P., 2000 In : Artificial Cells, Blood Substitutes, and Immobilization Biotechnology. 28, 1, p. 1-24
Therapeutic approaches for haemophilia
Hortelano, G., Ofosu, F., 2000 In : Expert Opinion on Therapeutic Patents. 10, 6, p. 929-938
Induction of angiogenesis by implantation of encapsulated primary myoblasts expressing vascular endothelial growth factor
Springer, M., Hortelano, G., Bouley, D., Wong, J., Kraft, P., Blau, H., 2000 In : Journal of Gene Medicine. 2, 4, p. 279-288
Persistent delivery of factor IX in mice: Gene therapy for hemophilia using implantable microcapsules
Hortelano, G., Xu, N., Vandenberg, A., Solera, J., Chang, P., Ofosu, F., 1999 In : Human Gene Therapy. 10, 8, p. 1281-1288
The in vivo delivery of heterologous proteins by microencapsulated recombinant cells
Chang, P., Van Raamsdonk, J., Hortelano, G., Barsoum, S., MacDonald, N., Stockley, T., 1999 In : Trends in Biotechnology. 17, 2, p. 78-83
Encapsulation of various recombinant mammalian cell types in different alginate microcapsules
Peirone, M., Ross, C., Hortelano, G., Brash, J., Chang, P., 1998 In : Journal of Biomedical Materials Research. 42, 4, p. 587-596
Permeability of alginate microcapsules to secretory recombinant gene products
Awrey, D., Tse, M., Hortelano, G., Chang, P., 1996 In : Biotechnology and Bioengineering. 52, 4, p. 472-484
Delivery of human factor IX in mice by encapsulated recombinant myoblasts: A novel approach towards allogeneic gene therapy of hemophilia B
Hortelano, G., Al-Hendy, A., Ofosu, F., Chang, P., 1996 In : Blood. 87, 12, p. 5095-5103
Growth retardation - An unexpected outcome from growth hormone gene therapy in normal mice with microencapsulated myoblasts
Al-Hendy, A., Hortelano, G., Tannenbaum, G., Chang, P., 1996 In : Human Gene Therapy. 7, 1, p. 61-70
Correction of the growth defect in dwarf mice with nonautologous microencapsulated myoblasts - An alternate approach to somatic gene therapy
Al-Hendy, A., Hortelano, G., Tannenbaum, G., Chang, P., 1995 In : Human Gene Therapy. 6, 2, p. 165-175
Growth of recombinant fibroblasts in alginate microcapsules
Chang, P., Hortelano, G., Tse, M., Awrey, D., 1994 In : Biotechnology and Bioengineering. 43, 10, p. 925-933
Sayyar, B., Dodd, M., Marquez-Curtis, L., Janowska-Wieczorek, A., Hortelano, G., 2015 In : Artificial Cells, Nanomedicine and Biotechnology. 43, 5, p. 318-327
Sustained expression of coagulation factor IX by modified cord blood-derived mesenchymal stromal cells
Dodd, M., Marquez-Curtis, L., Janowska-Wieczorek, A., Hortelano, G., 2014 In : Journal of Gene Medicine. 16, 5-6, p. 131-142
Cell-matrix Interactions of Factor IX (FIX)-engineered human mesenchymal stromal cells encapsulated in RGD-alginate vs. Fibrinogen-alginate microcapsules
Sayyar, B., Dodd, M., Marquez-Curtis, L., Janowska-Wieczorek, A., Hortelano, G., 2014 In : Artificial Cells, Nanomedicine and Biotechnology. 42, 2, p. 102-109
Strategies for ocular siRNA delivery: Potential and limitations of non-viral nanocarriers
Thakur, A., Fitzpatrick, S., Zaman, A., Kugathasan, K., Muirhead, B., Hortelano, G., Sheardown, H., 2012 In : Journal of Biological Engineering. 6,
Encapsulated engineered myoblasts can cure Hurler syndrome: Preclinical experiments in the mouse model
Piller Puicher, E., Tomanin, R., Salvalaio, M., Friso, A., Hortelano, G., Marin, O., Scarpa, M., 2012 In : Gene Therapy. 19, 4, p. 355-364
Single-colour flow cytometric assay to determine NK cell-mediated cytotoxicity and viability against non-adherent human tumor cells
Thakur, A., Zaman, A., Hummel, J., Jones, K., Hortelano, G., 2012 In : Biotechnology Letters. 34, 3, p. 447-453
Encapsulation of factor IX-engineered mesenchymal stem cells in fibrinogen-alginate microcapsules enhances their viability and transgene secretion
Sayyar, B., Dodd, M., Wen, J., Ma, S., Marquez-Curtis, L., Janowska-Wieczorek, A., Hortelano, G., 2012 In : Journal of Tissue Engineering. 3, 1, p. 1-12
Repeated oral administration of chitosan/DNA nanoparticles delivers functional FVIII with the absence of antibodies in hemophilia A mice
Dhadwar, S., Kiernan, J., Wen, J., Hortelano, G., 2010 In : Journal of Thrombosis and Haemostasis. 8, 12, p. 2743-2750
Monkey business for hemophilia management
Hortelano, G., 2010 In : Thrombosis Research. 126, 5, p. 365-366
Therapeutic applications of cell microencapsulation. Foreword.
Hortelano, G., 2010 In : Advances in Experimental Medicine and Biology. 670,
Characterization of viability and proliferation of alginate-poly-L-lysine- alginate encapsulated myoblasts using flow cytometry
Thakur, A., Sengupta, R., Matsui, H., Lillicrap, D., Jones, K., Hortelano, G., 2010 In : Journal of Biomedical Materials Research - Part B Applied Biomaterials. 94, 2, p. 296-304
Advances in Experimental Medicine and Biology: Foreword
Hortelano, G., 2010 In : Advances in Experimental Medicine and Biology. 670,
Early intraplatelet signaling enhances the release of human platelet PAR-1 and -4 amino-terminal peptides in response to thrombin
Ofosu, F., Dewar, L., Song, Y., Cedrone, A., Hortelano, G., Craven, S., 2009 In : Biochemistry. 48, 7, p. 1562-1572
Factors that contribute to the immmunogenicity of therapeutic recombinant human proteins
Mukovozov, I., Sabljic, T., Hortelano, G., Ofosu, F., 2008 In : Thrombosis and Haemostasis. 99, 5, p. 874-882
Encapsulated human primary myoblasts deliver functional hFIX in hemophilic mice
Wen, J., Xu, N., Li, A., Bourgeois, J., Ofosu, F., Hortelano, G., 2007 In : Journal of Gene Medicine. 9, 11, p. 1002-1010
Transplants for Hemophilia
Gómez-Vargas, A., Hortelano, G., 2007 Cellular Transplantation. Elsevier, p. 187-203
Sustained and therapeutic levels of human factor IX in hemophilia B mice implanted with microcapsules: Key role of encapsulated cells
Wen, J., Vargas, A., Ofosu, F., Hortelano, G., 2006 In : Journal of Gene Medicine. 8, 3, p. 362-369
An important role for the activation peptide domain in controlling factor IX levels in the blood of haemophilia B mice
Begbie, M., Mamdani, A., Gataiance, S., Eltringham-Smith, L., Bhakta, V., Hortelano, G., Sheffield, W., 2005 In : Thrombosis and Haemostasis. 94, 6, p. 1138-1147
Reduction of GAG storage in MPS II mouse model following implantation on encapsulated recombinant myoblasts
Friso, A., Tomanin, R., Alba, S., Gasparotto, N., Puicher, E., Fusco, M., Hortelano, G., Muenzer, J., Marin, O., Zacchello, F., Scarpa, M., 2005 In : Journal of Gene Medicine. 7, 11, p. 1482-1491
Continuous antigenic stimulation system (CASS) as a new immunization strategy
Gomez-Vargas, A., Rosenthal, K., McDermott, M., Hortelano, G., 2004 In : Vaccine. 22, 29-30, p. 3902-3910
Effects of genetic fusion of factor IX to albumin on in vivo clearance in mice and rabbits
Sheffield, W., Mamdani, A., Hortelano, G., Gataiance, S., Eltringham-Smith, L., Begbie, M., Leyva, R., Liaw, P., Ofosu, F., 2004 In : British Journal of Haematology. 126, 4, p. 565-573
Nonviral gene therapy approaches to hemophilia
Gómez-Vargas, A., Hortelano, G., 2004 In : Seminars in Thrombosis and Hemostasis. 30, 2, p. 197-204
History, challenges and perspectives of cell microencapsulation
Orive, G., Hernández, R., Rodríguez Gascón, A., Calafiore, R., Chang, T., De Vos, P., Hortelano, G., Hunkeler, D., Lacík, I., Pedraz, J., 2004 In : Trends in Biotechnology. 22, 2, p. 87-92
Cell encapsulation: Promise and progress
Orive, G., Hernández, R., Gascón, A., Calafiore, R., Chang, T., De Vos, P., Hortelano, G., Hunkeler, D., Lacík, I., Shapiro, A., Pedraz, J., 2003 In : Nature Medicine. 9, 1, p. 104-107
Polymer-encapsulated engineered adult mesenchymal stem cells secrete exogenously regulated rhBMP-2, and induce osteogenic and angiogenic tissue formation
Zilberman, Y., Turgeman, G., Pelled, G., Xu, N., Moutsatsos, I., Hortelano, G., Gazit, D., 2002 In : Polymers for Advanced Technologies. 13, 10-12, p. 863-870
Therapeutic levels of human Factor VIII in mice implanted with encapsulated cells: Potential for gene therapy of haemophilia A
García-Martín, C., Chuah, M., Van Damme, A., Robinson, K., Vanzieleghem, B., Saint-Remy, J., Gallardo, D., Ofosu, F., Vandendriessche, T., Hortelano, G., 2002 In : Journal of Gene Medicine. 4, 2, p. 215-223
Non-viral transfer approaches for the gene therapy of mucopolysaccharidosis type II (Hunter syndrome)
Tomanin, R., Friso, A., Alba, S., Piller Puicher, E., Mennuni, C., La Monica, N., Hortelano, G., Zacchello, F., Scarpa, M., 2002 In : Acta Paediatrica, International Journal of Paediatrics, Supplement. 91, 439, p. 100-104
Sustained and therapeutic delivery of factor IX in nude haemophilia B mice by encapsulated C2C12 myoblasts: Concurrent tumourigenesis
Hortelano, G., Wang, L., Xu, N., Ofosu, F., 2001 In : Haemophilia. 7, 2, p. 207-214
Gene therapy for hemophilia
Hortelano, G., Chang, P., 2000 In : Artificial Cells, Blood Substitutes, and Immobilization Biotechnology. 28, 1, p. 1-24
Therapeutic approaches for haemophilia
Hortelano, G., Ofosu, F., 2000 In : Expert Opinion on Therapeutic Patents. 10, 6, p. 929-938
Induction of angiogenesis by implantation of encapsulated primary myoblasts expressing vascular endothelial growth factor
Springer, M., Hortelano, G., Bouley, D., Wong, J., Kraft, P., Blau, H., 2000 In : Journal of Gene Medicine. 2, 4, p. 279-288
Persistent delivery of factor IX in mice: Gene therapy for hemophilia using implantable microcapsules
Hortelano, G., Xu, N., Vandenberg, A., Solera, J., Chang, P., Ofosu, F., 1999 In : Human Gene Therapy. 10, 8, p. 1281-1288
The in vivo delivery of heterologous proteins by microencapsulated recombinant cells
Chang, P., Van Raamsdonk, J., Hortelano, G., Barsoum, S., MacDonald, N., Stockley, T., 1999 In : Trends in Biotechnology. 17, 2, p. 78-83
Encapsulation of various recombinant mammalian cell types in different alginate microcapsules
Peirone, M., Ross, C., Hortelano, G., Brash, J., Chang, P., 1998 In : Journal of Biomedical Materials Research. 42, 4, p. 587-596
Permeability of alginate microcapsules to secretory recombinant gene products
Awrey, D., Tse, M., Hortelano, G., Chang, P., 1996 In : Biotechnology and Bioengineering. 52, 4, p. 472-484
Delivery of human factor IX in mice by encapsulated recombinant myoblasts: A novel approach towards allogeneic gene therapy of hemophilia B
Hortelano, G., Al-Hendy, A., Ofosu, F., Chang, P., 1996 In : Blood. 87, 12, p. 5095-5103
Growth retardation - An unexpected outcome from growth hormone gene therapy in normal mice with microencapsulated myoblasts
Al-Hendy, A., Hortelano, G., Tannenbaum, G., Chang, P., 1996 In : Human Gene Therapy. 7, 1, p. 61-70
Correction of the growth defect in dwarf mice with nonautologous microencapsulated myoblasts - An alternate approach to somatic gene therapy
Al-Hendy, A., Hortelano, G., Tannenbaum, G., Chang, P., 1995 In : Human Gene Therapy. 6, 2, p. 165-175
Growth of recombinant fibroblasts in alginate microcapsules
Chang, P., Hortelano, G., Tse, M., Awrey, D., 1994 In : Biotechnology and Bioengineering. 43, 10, p. 925-933